What makes Pyramid better for you than e.g., Falcon?
From your comment, it sounds like a lot of the value you've gleaned from Pyramid is based on the framework staying out of your way, so why not use something 5x faster that does the same thing? Does Pyramid provide some unmatched abstractions? (I'm coming from a position of no true experience in Pyramid)
You have event system, security abstraction, all kinds of overloading helpers for views and internal machinery that falcon doesn't seem to provide at least from my cursory look. Compare the size of documentation and configuration options between both projects.
Also looking at this http://klen.github.io/py-frameworks-bench/ the 5x better speed of falcon seems to be completly made up or occur in some very specific situation. More realisticly it looks like falcon can be 30% faster in some scenarios not involving storage - but for the price of giving you less options.
Which probably means that if you use any kind of storage the difference between those two can be ignored.
Django has grown up a lot in the last several years. It used to be really hard to use a different templating language, and I personally really dislike Django's templating language. That was the biggest turn off for me every time I looked into Django. If it had been pluggable earlier, this probably would've changed the calculation for me.
I've always thought of Pyramid as the ideal framework, conceptually. It feels like you're writing Python, not Pyramid, which is GREAT. Pyramid only shows up when you say "OK, I have my Python stuff; I need to make this show up in the web browser now." It is entirely unobtrusive. All frameworks should strive for that.
Unfortunately, the vast majority of frameworks take the opposite approach. Django at least used to be an example of that by forcing DTL (is this the abbreviation for "Django Templating Language"?) down everyone's throat, among other things.
I've also been very impressed by Chris McDonough and the rest of the Pyramid team. They're extremely helpful in IRC, they keep up the great work even after spending years as a small/niche framework, and their code is very clean and well-tested, not obnoxious or overcomplicated. It's a tight, consistent framework that stays out of the way and is just there to serve the developer, not to force him/her to comply. It is so everything a framework should be and so everything most frameworks aren't that I can't help but love it.
I haven't done a major Python-based web project for many years (have one in progress, porting a Rails-based site to a Mezzanine-based site, but work on it only rarely), so I'm sure some of this is outdated.