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A comment on One Man’s Quest to Hack His Own Genes.

Re:One Man’s Quest to Hack His Own Genes by gravelc on Wednesday January 18, 2017 @07:19PM (#13431823)
He's not 'hacking his own genes' though, is he? There's no modification of his germ cells, nor is there stable incorporation of the exogenous material into the genome of the affected cells - more just transient expression of the protein he's interested in.

Giving the extraordinary complexity of the ageing process, with the interplay between multiple genes, each with multiple splice variants and post-translation modifications, and whose expression is modulated by both genetic and epigenetic factors, the chance of success with this approach is minimal.

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Re:One Man’s Quest to Hack His Own Genes by tmearnest on Wednesday January 18, 2017 @07:48PM (#13431969)
It's an interesting first step to hacking one's own genes, though. It makes me wonder if it would be possible to transfect human skin cells in situ with a plasmid containing a gene for a fluorescent protein. If possible, it would be the nerdiest of nerd tattoos.
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