No. Blender's UI is initially impenetrable but once you work it out it becomes second nature. GIMP's UI is initially impenetrable and once you work it out it seems even worse than you thought.

Edit: In fact, I think GIMP and Blender have kind of opposite UI problems. GIMP tends to go along with the obvious toolkit defaults, making no concessions to usability, whereas Blender reinvents everything from scratch for efficiency, making no concessions to convention.