Creativity includes discovery and invention. I would assume that if you put all your eggs in the basket of discovery, then you are kind of just throwing the dice. (on Rumsfeldian "unknown unknowns")

That's why Elon Musk says he didn't pursue his idea of using capacitors as batteries. It relied too much on whether or not there was something to be discovered. So he went with things that definitively could be built, where he was sure that "success was at least a possible outcome." ("Known unknowns")

So I would think that you should choose your project wisely, where, again, you can be sure that success is at least possible.