$300 is affordable, and prices will come down further.
If you want MacOS support, only that BizonBOX /says/ it will work. But I betcha they all will. I certainly wouldn't be the guinea pig, though-- wait for other people to try it out and post their experiences.
The "much more powerful PSU" you speak of appears to be a Dell DA-2 laptop power supply, which isn't that powerful compared to say an 800w ATX PSU.
Tell me that this isn't an Akitio TB2 with holes drilled in the side: https://bizon-tech.com/us/bizonbox2-egpu.html
I've built a couple of these from Akitio and Sonnet enclosures (first one took ages to get working, otherwise it saved me from the huge disappointment of the most recent MBPr).
The BizonBox 3 does indeed come with a 200w laptop PSU. But that is plenty for a GTX1080 with a 180w TDP.
1 - https://youtu.be/vvAB3U5umug?t=187