Where do you see this? I see Greater Boston, Albany, Ithaca, State College (Penn State), Greater DC, Charlottesville (UVA), Raleigh-Durham, Ann Arbor (UMich), Urbana-Champaign, Madison (UWisc) in the 'brain gain' category, all anchored by one or more strong universities, while a few smaller metros in Rust Belt states that are missing these amenities and are on the rural periphery are showing in 'brain drain'.
The culture in the area is great, and there's no better place for a craft beer enthusiast to live. Couple the excellent job market with the low cost of living, and it's a hell of a nice place to live. Of all the places I've lived, it's by far my favorite.
VA drain: Lynchburg; gain: nearby Charlottesville, Roanoke, Richmond
MD drain: Cumberland; gain: nearby Morgantown (WV), greater DC
PA drain: York; gain: nearby metro Baltimore (MD), greater Philadelphia, State College
OH drain: Toledo, Lima, Mansfield; everywhere else neutral
GA drain: Valdosta, Macon; everywhere else neutral
I think that just looking at blobs of color is not particularly useful as some metro areas are much much larger than others.
Until you factor in cost of living. Last I checked Austin has lead in cost-of-living-adjusted salaries for the last few years.