"Pickle", Python's old seralizer, had a similar leak problem. It has a cache. You can reuse a Pickle stream, which is done in interprocess communication. But the cache of previously-send objects wasn't being cleared at the end of each Pickle block. I found that, did a workaround, and submitted a bug report. Not sure it was ever fixed properly.
I still have a bug report in on CPickle, a "faster" implementation of Pickle written in C.[1] In a complicated situation with multiple threads using CPickle, memory becomes corrupted and the program will crash. It doesn't happen using Python Pickle, so I just quit using CPickle. The bug report got the usual "reproduce in a simpler situation" reply to make it go away, and the bug report remains open. It may be the same bug as this one [2] from 2012, although I doubt it.
For parsing HTML, I use html4lib. It's slower, but it's all in Python.
[1] http://bugs.python.org/issue23655 [2] http://bugs.python.org/issue12680
Indeed, Python packages built over C extensions can be quite hard to debug, as seen with lxml. But what makes it even harder is the fact that lxml is partly built using Cython... so you deal with Python code, C code generated with Cython, and pure C code (libxml2).
On the other hand it is a radically simpler way to write bindings that also contain logic, or to write rather fast code without straying to far from Python. Plus, it can cythonize almost all code, even very dynamic code with closures, which will still often improve performance on it's own (no interpreter, but still Python runtime for every op). And that is then a nice base to do further optimizations.
I think I'll stay away from it in the future. Unfortunate, since it's the fastest HTML parser in Python that I know of.
With stanzas like
for event, n in ElementTree.iterparse(xmlfile, events=("end",)):
if n.tag == "blar":
# do stuff
n.clear()
it doesn't even take much memory to parse files of arbitrary size.