I find Econtalk discussions meaningful and rigorous, in contrast to carefree series like "99% Invisible" / Invisibilia / Startup. The latter are great as a chewing gum for the brain, but they are mostly trivia and I do not recall learning anything useful from them over the years.
It's notable that he's getting better over time. I started listening to the more recent ones, then went back and listened to the old ones, and they were quite a lot worse.
Off the top of my head, my favorites have included the episode about how the budget gets passed in the US, the one about justice and the prison system, the food bank market where food gets priced for exchange, and the one about medical ethics and the question of "too much information".
I'd love to have an "EconTalk meetup" in the bay area.
He probably skews a bit libertarian for the typical HN'er to agree with, but he gives voice to a lot of points of view, and he brings on good guests. At least half of the podcasts have sufficiently interesting titles that they could be easily voted to HN front page, and the depth of discussion is good for the hour each guests receives.