You left out a bit. If we take Wikipedia's definition (I know, I know):
> The second law of thermodynamics states that the total entropy of an isolated system always increases over time, or remains constant in ideal cases where the system is in a steady state or undergoing a reversible process.
As far as is currently known the laws of physics are time-reversible, which (ISTM, at least) would imply that the latter clause could very easily apply to the universe as a whole.
(There's also the issue of whether the universe itself is a closed system.)
And yes the definition of "universe" is something I define as "a closed system that doesn't interact with other systems", which is also a consistent definition even if the multiverse theory is correct. If two things interact then they are by definition in the same universe.
So you ask what is the ultimate MOST NEGATIVE entropy that exists? Life. Specifically brains. Life forms are the most ordered things in the universe (non-random/order). Brains are massively large negative entropy locations in the universe. If you total up all positive entropy and negative entropy the balance out to zero. The reason is because the laws of physics don't change and DO create patterns.
You can even study this "Zero Entropy" law in Conway's Game of Life. As the randomness increases over time to does the 'order', and i argue that the roughly cancel out. It's a kind of 'information conservation' at work here. If no new information is added into a system, it cannot gain or lose entropy, because all the random events are creating 'patterns' and by definition a pattern is an non-randomness and therefore negative entropy.