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Re:Interfacing with the Arduino's bootloader directly from C... by nzjrs on Saturday December 03, 2016 @10:37AM (#13096043)
Related question, but has anyone come across code to do this in python?
Re:Interfacing with the Arduino's bootloader directly from C... by shakna on Sunday December 04, 2016 @02:00AM (#13099092)
There is a Spanish blog by someone that managed to upload the hex over WiFi, using Python. An English write-up is here [0], and links to the original.

[0] http://hackaday.com/2014/11/13/programming-an-arduino-over-w...