Most places will not take your resume seriously if you don't have a degree attached. Startups tend to be more lenient sometimes, but Big Corp. isn't going to touch you without a degree, nor will you have a promotion path without one.

It's the reality of the situation, and until there's a significant change in attitude, not having "a" degree is going to hurt your career prospects unless you're a wildly successful entrepreneur or have great connections/independently wealthy.