Fluoride collects in your pineal gland. There is no study (AFAIK) that says it harms the function of the pineal gland, but when I armchair-researched this a few years ago, it seemed no one is quite sure that it is benign.

The most significant benefit from brushing comes from the mechanical action, not from the toothpaste or any compound within. Personally, I use fluoridated toothpastes, but I can understand people who don't.

People like to point to scientific consensus as proof (by authority), but consensus changes with time: Trans fats are no longer good. Fats are no longer bad. Stomach ulcers are now caused by bacteria. Cholesterol intake no longer matters. Dinosaurs are no longer extinct (they are birds now), and had features. Patient zero did not bring HIV to the US.

It may or may not be benign. But I know that fluoride prevents cavities by reinforcing your enamel and that's why the ADA recommends it. So whatever the accumulation of fluoride does to my pineal gland, I'll trade that for the protection fluoride affords.

I know unfluoridated toothpastes are clinically proven to work in cleaning your teeth. But I need anti-cavity protection too.

(My mom's a dental hygienist. She'd kill me if she found a cavity.)