I used to be pretty good at touch-typing to them back when lots of games used the F keys (Mechwarrior series, Dark Forces II, X-Wing, that sort of thing). These days just mashing in the general area of F4/F5/F6 (quick save in many games) is all I can manage without looking.

I've also gotten worse at the number row now that few games use more than the first 3-4 for quick slots or weapons.