I have made this transition in stages with the same company (office-based --> home-based but working closely with regional clients and teammates --> home-based and don't see anyone else much). Motivation and discipline are still occasional issues. I am definitely inspired by working physically next to a colleague. For me, I find a morning routine is a critical component of a successful day (consistent wake-up time, consistent set of activities before working, etc.). To feel like I am "part of something", I try to focus clearly on the business needs my work resolves. I work to maintain a perspective that shipping a batch of work will definitely lead to a particular experience for colleagues or users.