I've used both Knockout and Vue for frontends that needed to render reasonably large amounts of disparate elements with near real-time updates, so I think I can answer this. Knockout is nice but feels closer to jQuery in that it requires a lot more discipline on the behalf of the developer to organise and maintain code. Things like ObservableArrays means dealing with another layer of abstraction; the wonderful thing with Vue is that it's just native JS objects all the way down. It also has a better structured child/parent component model with event flow, not to mention being much faster for rendering. I would also recommend Vue over Knockout.