I doubt it. Thiel's personality - in all his public appearances - has been hyper-rational, not exactly the sort who would hold onto a childhood dream for 20 years. And he's talked about how falling off that track was the best thing that ever happened to him - so much so that he now wants to help other talented college kids fall off the established track.

Also, he's not U.S. born, which disqualifies him from being president anyway. He could potentially seek some other office...but I really doubt that he would want any position that makes him just like 99 other or 434 other people.