Probably my biggest annoyance with OpenGL mode is that it completely changes the UI logic form standard mode (arguably it makes the interface more Windows-like, or probably Altium-like). The standard mode UI is weird but surprisingly usable so I tend to do most of the layout work in standard mode and only switch to OpenGL to use push-and-shove to avoid major ripup-and-reroute cases and for diff-pairs/length matching.