Even then it would have extremely struggled to handle 30+ million new cases of Small Pox, TB, Bubonic Plague, etc.
Luckily as far as modern technology can show we're extremely certain Mars has no life we'll accidentally genocide while exploring/terraforming.
Indians had no trouble crisscrossing America.
A single smallpox laden explorer would have started a plague in the Americas and a single native American would likely have died of one of the many plagues in Europe that Europeans had grown up with (and still often died from).
The problem of safety is not always placed on the explorer, sometimes the explorer is the danger to his environment.
Well yeah there weren't any human infectious illness where... there aren't any humans.
This video explains the history of man kind's infectious illness very well https://www.youtube.com/watch?v=JEYh5WACqEk
If there is intelligent life (or, any life as we define it generally), there's a pretty high likelihood our arrival could damage it, especially if we don't discover it until after arrival. (And "really especially" if we go the terraforming route)
2- I'm not so anthropocentric as to think that the only value in the universe is human value. It's not our universe; we're an infinitesimal fraction of it. Other life has inhabited earth for billions of years, and maybe other places too. The terrestrial or extraterrestrial environments have value for existing and future life, regardless of whether that is human life. And most of life isn't human, and won't be in the future either.
Beauty is really subjective.
Also, I think there are only finitely many eventually observable planets in the universe?
You've got to be kidding. What "wonderful discoveries" do you think there's going to be out there?
There might really be alien civilizations and worlds with lush vegetation out there somewhere, but for the foreseeable future, we're going to be limited to our own Solar System. The worlds here are not unknowns: we've been observing and probing them for many years now, and we know pretty well what's on them.
There's all kinds of interesting things on these worlds, from a scientific perspective: gas/ice giants, oceans of methane on Titan, a weird hexagonal pattern in Saturn's atmosphere, ice mountains on Pluto/Charon, etc. But we're finding all this out just fine using robotic probes. I'm sure we'll find out more, and refine our knowledge further, with continued robotic missions.
But if you're thinking that there's any good reason for humans to fly around the solar system and live on other worlds here, there just isn't any good case for it: none of the other habitats are remotely livable (the closest is the upper atmosphere of Venus of all places, if you really like the idea of living in a dirigible), and so the only real economic case to be made is mining. Most likely, we'd get a lot more mineral resources out of asteroids rather than planets or moons.
But this isn't like Star Trek with all kinds of fantastical worlds out there to discover, plus alien cultures to make contact with. They might be out there, way out there, but we're still struggling with the idea of how to travel to our very nearest neighboring star system (Alpha Centauri), which is about 4 light-years away. Maybe this will all change if Zephram Cochrane invents the warp drive, but for now, there just isn't much reason for humans to do anything more than basic science missions in space, and hopefully asteroid-mining missions in the near future. We're not going to make any huge new discoveries any time soon, just more thing like "ooh, look at these weird ice mountains on this dwarf planet!". That's really interesting, don't get me wrong, and a great reason to send a robotic probe, but it's not like we're going to discover anything truly groundbreaking here in our own system. According to all our data, all the other worlds here are lifeless rocks or frozen wastelands or gas giants. This isn't such a great "time to be alive"; that time was back in the 60s-70s when they were first discovering stuff in space with the Apollo missions and various probes like Voyager, Mariner, etc. (and maybe in the 2000s when all the pictures from the Mars rovers started coming in; but how many pictures of red rocks on a red sky do you need to see before you realize there's nothing more to Mars than that?).
It just isn't like the days when "the New World" was discovered, and Europeans were able to learn of and bring back fantastic new foods like cocoa/chocolate, maize/corn, learn about new cultures and brutalize them and steal their gold, etc. It's much more like exploring Antartica: it's a very interesting place for scientists, and absolutely worthwhile to do science missions on, but for everyone else the only possible reason you'd go there is as a tourist for a very short time because it's uninhabitable (though far more easily inhabited than Mars; at least there's breathable air there, and plenty of water just lying on the ground, there's even penguins and fish if you get hungry).
It was Indigenous People Day yesterday in the US (aka Columbus Day), and it made me think what an interesting time it must have been to be alive at a time where there were widely mostly unexplored areas in the world, and how incredulous and shocked people must have felt when they found out of these unexplored lands (putting aside the fact that it had been explored and lived by other cultures they did not know of).
Then I realized I do live in a time like that, with space exploration being that next frontier. What a time to be alive. I can't wait to be in absolute disbelieve of all the worldful discoveries that will be made when we expand space exploration further.