Somebody's already done one in C: https://eviltrout.com/2015/06/29/an-emulator-for-tis-100.htm...

And according to Zach, the intended market wasn't just programmers (which is why he explicitly killed bit manipulation, and the largest number a TIS-100 register can hold isn't a power of two), and I've heard tales of non-programmers enjoying it.

Then again, if you like Zachtronics games, especially TIS-100, then have I got a hobby for you...