I saw Dr. Karr present the Whole-Cell Computational Models a few months ago and I believe it's truly transformative work. Once you wrap your head around what they do, you'll understand the limitless potential this software could have. If you're interested, I think these two articles can give you a good idea of what Whole-Cell Modeling is: http://www.cell.com/cell/fulltext/S0092-8674(12)00776-3 https://covert.stanford.edu/publicationpdfs/DMacklin2014.pdf.

I applied to work with them at the time but they were low on funding. I would apply today if I weren't already happily employed. Good luck Karr Lab!