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Re:Investigating a malware sample which sometimes fails to b... by null_0 on Saturday September 24, 2016 @09:34PM (#12573441)
There is a large body of academic research on the topic. Here's a few to get you started:

Emulating Emulation-Resistant Malware https://people.eecs.berkeley.edu/~dawnsong/papers/2009%20emu...

Detecting Environment-Sensitive Malware http://www.syssec-project.eu/m/page-media/3/disarm-raid11.pd...

Revolver: An Automated Approach to the Detection of Evasive Web-based Malware https://www.usenix.org/system/files/conference/usenixsecurit...

MalGene: Automatic Extraction of Malware Analysis Evasion Signature: https://www.cs.ucsb.edu/~vigna/publications/2015_CCS_MalGene...

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