In Rebol / Red...

  >> "Hello" != "hello" 
  == false
  
  >> "Hello" !== "hello"
  == true

!== is a stricter equal [1] where both values must be of same type and is case sensitive on strings, chars & words.

[1] see strict-equal? function - http://www.rebol.com/r3/docs/functions/strict-equal-q.html