Yes and no. When a member of Congress is deciding how they feel about an issue (in the rare example where the party line hasn't already dictated it), I think it's unlikely they think about specific individual voters in their district.

I know when it comes to votes on our borough council, those council members think about their neighbors, the guy down the street, etc. Now they're only representing about 2k people each, but it's not hard to imagine that if you represent 30k people, only a fraction of whom are politically active, you're much more likely to think of individual voters than if you represent over 20x as many people.