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Re:Show HN: I invented a caffeinated toothpaste by personlurking on Thursday September 15, 2016 @06:19PM (#12510319)
> Our toothpaste gives you a quick caffeine boost that works as soon as you start brushing, even faster than coffee.

I read that caffeine in coffee form takes 15-20 min to be felt by the user. I'm curious how the toothpaste form works on the spot.

Re:Show HN: I invented a caffeinated toothpaste by btym on Thursday September 15, 2016 @07:42PM (#12510794)
I tried to find some comparable studies, here's one that seems particularly relevant, showing the effects of caffeinated gum:

http://www.militaryenergygum.com/wp-content/uploads/Bioavail... (take a look at the second graph)

TL;DR: Yes, even with oral absorption, you probably won't feel anything after 5 minutes, and you'll be wired at 15 minutes.

This toothpaste definitely won't work "on the spot", but 10-15 minutes is still quick enough to get you going by the time you're dressed and out the door.

Re:Show HN: I invented a caffeinated toothpaste by girvo on Thursday September 15, 2016 @07:31PM (#12510733)
Sublingual administration of certain chemicals allows for they bypass of first-pass metabolism; basically going from the thin membranes in your mouth directly into your bloodstream.
Re:Show HN: I invented a caffeinated toothpaste by riboflava on Thursday September 15, 2016 @06:56PM (#12510550)
Placebo effect.
Re:Show HN: I invented a caffeinated toothpaste by eric_h on Thursday September 15, 2016 @07:32PM (#12510740)
I disagree - psychoactive substances applied to the gum are absorbed into the blood steam much more rapidly than those ingested.