But it takes a lot of experience to imagine what a frame that looks great on a ~24 inch monitor will look like when projected in a theater.
I would strongly recommend that anyone dreaming to screen something in cinemas make a deal with their local cinema in order to do test screenings - to check picture and sound. Just like with anything else, there's no substitute for testing under "real" conditions.
Note that most(?) cinema setups will happily take some form of digital audio/video signal and run it through dolby surround and project it - so you don't have to start testing with a DCP file. But you certainly should test that in a cinema before distribution.
Also note that the "player" part of a fixed installation might have quirks/bugs that software that's more easily updated might work around (think mplayer vs a cheap old DVD player).
DCP can be a pain in the ass for indie filmmakers, though. These days it's easy to generate a DCP from footage, but basically impossible to test it without actually putting it through a DCP projector in a cinema. This is crazy.