More like 'Game Over, site loses'. Because whether they like it or not, a lot of people won't assume 'broken site' means 'adblocker is messing up scripts'. They'll assume the site or service is just busted.

Congratulations, you now have a reputation as a poorly done site which doesn't work in a lot of browsers for reasons seemingly unknown.

And then there's the effects on SEO, or heck, various thousands of services that need to get some content from the sites mentioned to work properly.