I used to love Python when I came to it years about after slogging along through QBasic, VB6, C++ and C, but in this day and age, it doesn't really offer much to me over doing things in modern C#, especially on the CLR. I appreciate some of the changes that were made to the runtime to support IronPython, like dynamic support and the DLR, but if I'm going to be doing something not-C#, then I'd rather go towards F#.