There is the "Workstation in a Mouse"

http://www.ultratechnology.com/scope.htm

Bit of a toy demo though since it only ran a single fake program.

A chess game: http://www.ultratechnology.com/chess.html

The largest serious suite I know of is a VLSI CAD/simulator for silicon chip design:

http://www.ultratechnology.com/okad.htm

http://www.ultratechnology.com/okad2.htm

Pictures of it in action: http://www.ultratechnology.com/tape1-2.htm