IDK about statistical difference, but the mechanical difference between a brand new high-end full-size car and a twenty year old Honda Civic is going to be massive. Just look at the downward slope of that curve of fatalities per billion miles in each year. Also remember that those numbers are averages over the entire car population in each year, so most cars in the 2015 data are quite a bit older than 2015.

If we had data for the "high end modern full-size car" category, it would most definitely be lower than 10 fatalities per billion miles.