As in, we should consider why we have planes in the first place: it's to deliver some payload (bombs, missiles, or in the olden days, cameras for photography) to a specific place where you make use of that payload and then go home. Once you remove the human, you're not left with too many uses that can't be solved with existing technology.
http://www.boeing.com/history/products/himat-research-vehicl...
Rudimentary fuzzy logic in this kind of platform should be able to defeat a human pilot regardless of the pilots cunning/unpredictability/other human aspects which movies trump as superior human features. But, practical requirements such as range, payload, loiter time, pork barrelling may mean that the platform is otherwise compromised.
Additionally in an era where things such as airborne lasers are becoming a reality, the whole meta may completely change.
I'll grant you that doing this in the US is going to be problematic because of ethical concerns, but there is definitely going to be some country that does it, and as soon as they do, they'll instantly gain air supremacy.