One example would be Resveratrol, that mimics caloric restriction. For exercise, the challenge seems to be quite hard (http://sydney.edu.au/news-opinion/news/2015/10/02/exercise-i...), but there can be seen some progress in animal models (https://www.washingtonpost.com/news/to-your-health/wp/2015/0...).
Everyone can exercise, no matter what condition: bad heart, missing lung, missing limbs, etc. There is some form of exercise that can be done. You name a condition, I'm sure I can find someone on youtube with that condition absolutely crushing a work out.
Honestly, considering the overweight and obese population is growing we have a problem with systemic overeating that needs to be corrected first. It doesn't matter how much exercise you do if you eat more than you need.