I'd so try a ketamine based product, despite the fact that its regular use is for general anesthesia ... If I remember correctly even SSRIs were "accidentally" discovered by observing metabolizing effects of - and I hope someone corrects me here if I'm off - cough syrup.

Dicking around with the chemistry of ketamine to make it safe and therapeutic as well as pre-cursory enough for consumption to generate the desired effect could take years though, and there still might be issues even then that would prevent it from general use....

Bit off topic - if there's one place where I am for patents, it's for pharma - takes years to find something that works, and when they finally do, it's only natural that they would want to recoup the money.