Learning a fact physically "records" the fact in the brain, but is it well-established that powerful learning experiences can cause changes to the overall functioning of the brain?

I mean, not the physical changes that amount to "now your motor neurons have changed so that they swing a golf club more accurately" but physical changes that are like "now your motor system or learning system or the regulation of something seemingly unrelated is structurally different because you've been seeing/hearing/thinking these things" ?

I'm not talking about a memory "subsystem" being changed so that it now contains and remembers the incident; that's the usual function of it; I'm talking about the memory (or other) subsystem being changed so that it is now somehow fundamentally altered, processes things differently from its normal function, or fails to process something that it could before.