I just mean in terms of potential addictiveness. Mind you, weakly binding drugs will usually be coupled with higher doses. So there's not exactly a separation between time-to-action and length-of-action and binding affinity. Dont worry about coatings and whatnot. If someone wants to abuse a drug, it will most likely be crushed up. Now, if we are talking about the actual substance - depending on whether it is a direct agonist versus a prodrug that goes through multiple passes, or has other rate limiting behavior. -- This will definitely affect the addictiveness of the drug. But 100% in addition to the binding affinity and the receptors affected. So I agree, it's a combination of a bunch of factors. But the ultimate end result, which is perceived duration, perceived impulse, is responsible for a large part of the addictive threshold of that drug. The drug's makeup is clearly responsible for everything, I'm not saying perception trumps the actual chemistry. I just mean, if there is very little perceived impulse, there will most likely be little to no physical dependency. Again, this is based on the tendency of someone to use a drug at what we want to call effective doses, or in abusing it, supra-effective doses.