It's doable so long as everyone involved is bought in. We have a two and a bit year old and I work from home full time, with the odd visit to the office for planning sessions. The reason it works is that my wife treats me being in my study in much the same way she would me being in an office elsewhere, but with the perks of me being able to see her and our son when I come out to make some tea or have lunch, and without any commute time. If you don't have a space in the home which you can close the door on and call work being remote isn't going to last long.