This library seems to be implemented in C so that higher level languages can make use of it. C is much simpler to interface than C++. For instance, you mention WxWidgets, but that thing is so god-damn complex that there's still no stable WxPython for pyhton 3..
I really hope that this libui stays as just a simple simple thin wrapper so that we can build complex things no top of it in each language. For instance, python guys may create a declarative framework on top of this while lisp/haskell guys may create a Functional Reactive "thing" on top of it. As long as libui stays simple enough, everyone can extended it in ways that make sense for their own languages..
I did a project last year where I wanted to use SWT, but I wanted to write the program in Python, and use CPython rather than Jython so I could have access to C extension modules like lxml. So I hacked up a solution using the Avian lightweight JVM and the pyjnius JNI-based Python/JVM bridge from the Kivy project. I should release that sometime.