I have never been a fan of the concept. You have to work really hard to force an interesting thought into 140 characters, which leads most people just post throwaway snark and dark humor. And reading backwards through a chain of posts to simulate a real post is just stupid. I made several attempts to use the thing, anyway, because "everyone else was using it."

I eventually came to use 2 accounts, one anonymous, to interact with brands and personalities (but I repeat myself), and one personal, to keep up with people I knew first-hand. The former devolved into just ranting about everything that I found sub-optimal (usually about the .NET workflow for my day job), and the latter didn't generate enough interesting activity to care about. Both were just negative pressures on my daily activity, so I finally just shut down both.