SRFI-110 says you can^1: "Sweet-expressions are general and homoiconic, and thus can be easily used with other constructs such as quasiquoting and macros. In short, if a capability can be accessed using s-expressions, then they can be accessed using sweet-expressions. Unlike Python, the notation is exactly the same in a REPL and a file, so people can switch between a REPL and files without issues. Fundamentally, sweet-expressions define a few additional abbreviations for s-expressions, in much the same way that 'x is an abbreviation for (quote x)."

http://srfi.schemers.org/srfi-110/srfi-110.html#wisp

^1 [ed: well, not "just python syntax", but if you wanted that, you would be better off using python. But python-like syntax/skin is absolutely doable. ]