It's not unlike many college kids taking a job as a security guard and "watching monitors" while doing their homework, etc. (Another thing that I considered, but never actually did.)
Of course, there's a lot more training for truck driving, but I don't see that as a major barrier, given the benefits of extra pay and travel.
1) Automated gears and obstacle detection - we already have this. 2) Have the truck stay in one lane and maintain distance - We're close. This means humans stay in truck and solve the hard problems when encountered. (Kind of like pilots) 3) Automated port to port driving without humans. 4) Destination to destination driving without humans.
We already fly military aircraft remotely, I don't see why a truck that's packed with cameras and sensors can't be driven safely by a human in an office somewhere.
In the states, many distribution centers are located next to major transportation arteries, whether rail or interstate highway. In addition, many of the places they ship to are also located on major arteries. It wouldn't be a huge stretch to have automated trucks you load on one end, they drive to the other (using 98% highway driving), then park in a waiting area until a human finishes the job by parking them.
The interesting edge cases here would be accidents, construction, and detours. Whatever you deploy should be able to handle those without human intervention. Otherwise we could end up with every accident site also having 100 automated trucks at a dead stop waiting on drivers to show up. That'd be ugly.
I wonder if there will be a more specialised role for human drivers here akin to pilots in ports. Companies at the scale able to invest in the tech might have the trucks arrive at a queue near regional hubs and have wet-ware do the 10 minutes of fiddly driving after clearing off the Smart car debris.