Short of large hardcover books, I can't say I've ever read two-handed. Perhaps I have larger than normal hands. but every book I've ever owned (and most books I've checked out from various libraries) I read one handed.

I object greatly, and think that single handed holding is an extremely important spec. Far more important than some silly touch-screen.

But like books, we are all different. So I hope you enjoy your e-reader however you choose to read it.