Is it really hard to pilot a spaceship? You maneuver it out of the solar system (should not be _that_ difficult, certainly not if your destination is in a direction outside of the ecliptic), point it in the right direction, move to full throttle, and let it do its thing for a few centuries while you sleep or watch history on earth go by.

Yes, there's a risk you may hit something and be killed, but per passenger mile, I expect it to be even safer than the space shuttle.