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Re:PyPyJS – PyPyBox by beagle3 on Sunday March 20, 2016 @07:02AM (#11322495)
Skulpt does require a VM, but e.g. Brython, RapydScript, PyJs and a few others do not.

Transcrypt seems to maintain a closer correspondence between source python and javascript, making debugging perhaps a little easier. But it doesn't look like it brings anything significantly new to the table.

Re:PyPyJS – PyPyBox by AnkhMorporkian on Sunday March 20, 2016 @10:20AM (#11322996)
The big thing it brings to the table is file size. The overhead is a few kilobytes, whereas the Brython runtime (the other smallest one I know of) is 110KB.