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Re:Caffeine use disorder by TTPrograms on Monday March 14, 2016 @03:26PM (#11284929)
There's also a gene that determines if you're a fast or slow metabolizer, I think it affects half life by around a factor of two. 23AndMe checks the associated SNP.
Re:Caffeine use disorder by danieltillett on Monday March 14, 2016 @05:41PM (#11285789)
Yes this is true. I should have added these times are averages, not constants.

Metabolism of drugs like caffeine is genetically quite variable and is quite an issue for pharmaceutical companies.