Re:Why huge gains in drug discovery tech have led to longer ...
by searine on Monday March 07, 2016 @03:35PM
(#11241415)
>This goes back to the phenotypic screening argument.
Truth. Domagk would have missed sulfa all together if he had been using an in-vitro strep model.
Prontosil (what Donmagk discovered), and azodye connected to a sulfa molecule, must be enzymatically digested into the individual azo and sulfa molecules before it becomes biologically active.
Sometimes reduction of a problem, looses the problem all together.
Truth. Domagk would have missed sulfa all together if he had been using an in-vitro strep model.
Prontosil (what Donmagk discovered), and azodye connected to a sulfa molecule, must be enzymatically digested into the individual azo and sulfa molecules before it becomes biologically active.
Sometimes reduction of a problem, looses the problem all together.