It doesn't matter (for example) if I am/am not comfortable with ES2015 syntax. A junior developer already made that decision for me when he decided to implement the modal window by adding React, Babel, and Webpack to the project, instead of just writing a two-line event listener and a CSS class. Meanwhile, my colleagues are standing at the kegerator toasting his choice, because how could we ever have maintained or optimized such archaic vanilla JavaScript before without arrow functions and DOM diffing!?
React is not bad. In fact, it is great. But instead of being "an option" it is becoming "the default." Sadness results from being forced by industry trends into using it everywhere, despite knowing that it doesn't solve any problems that I did have while introducing new problems that I didn't have.
I think the JS fatigue we're seeing is because web development is now largely a mature industry. React is roughly the 4th generation of Javascript technologies (1st = DHTML/Layers, 2nd = JQuery/Prototype/Mootools/YUI/Ext/Dojo, 3rd = Angular/Ember/Backbone, 4th = React/Polymer). At this point, there are millions of JS developers, they have seen multiple generations go by, and they just want some stability. The folks who always want to be on the bleeding edge are off doing IoT and VR startups.
IMHO, React is a nice piece of software, but it's a nice piece of software entering a market where existing solutions are already pretty good and much of the action is moving elsewhere. They have to hype it up, because people won't give up their JQuery/Angular/VanillaJS otherwise. It's a very different situation than when JQuery was introduced and web development was recovering from the .com bust and years of stagnation in browser innovation.
Sorry to be brutal but. Fuck no it's not. An hours studying of the JavaScript ecosystem should be more than enough for most to see that not only is web development not mature its mutating and beginning to try to consume other programming disciplines like some form of cancer. Just look at how NodeJS has been creeping its way from server to desktop to mobile.