Depends on your definition of "make a difference in practice". If you mean "make the language become one of the dominant ones", yeah, that doesn't seem to have happened. Either Lisp is less effective in the large than one would expect from its power, or it's less powerful in practice than people think, or power has almost no relation to language dominance.

But if you mean "make a difference to the user", well, it lets the user more easily write the program that the user wants to write. In practice, that makes a difference - to that user.