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Re:iTerm2 Version 3 Now in Beta by withjive on Friday February 19, 2016 @05:03AM (#11132641)
What you are looking for sounds a lot like TMUX + Bash (scripted tmux setup). Then you can run that inside of iTerm.

Tmux supports tabs and dynamic splits nicely via ncurses.

Also check out tmux ressurect [1] for saving tmux session persistence.

[1] https://github.com/tmux-plugins/tmux-resurrect

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