Yes it would. But from a blocking-the-offender perspective, it would be equivalent to blocking the offending IPv4 address.

In v4, you block the offending address and you block all the NATed devices behind that v4 address.

In v6, you block the offending prefix and you block all the (non-NATed) devices behind that prefix.

In both cases you block an individual compromised subscriber, no matter whether only a subset of their devices are compromised.