While there are some drugs that are clearly effective, there are big problems in Big Pharma's approach to clinical trials, including burying half the trials' results and poor experiment design. And once a drug makes it to market, expanding that market without testing becomes a priority. Do you think Risperdal was a one-off, or is it a representative case study of how drugs are marketed by at least a major part of Big Pharma?
For example, Ben Goldacre. He is cynical about 'Big Pharma', and has written about it in one of his books[0]. At the same time he appears to support efforts to open up private medical research -- he recently cofounded AllTrials[2] along with the BMJ, Cochrane, PLOS, and a few other high-profile reputable sources[3].
[0]: https://en.wikipedia.org/wiki/Bad_Pharma [1]: http://www.cochrane.org/ [2]: http://www.alltrials.net/ [3]: http://www.phc.ox.ac.uk/news/ben-goldacre-joins-oxford-unive...