Chemical clears Alzheimer's protein and restores memory in mice

Re:Chemical clears Alzheimer's protein and restores memory i... by ridgeguy on Thursday December 17, 2015 @09:18AM (#10751534)

Don't have the paper in front of me, but IIRC, the test dose ranged from 10mg/kg to 100mg/kg. A branch of the study looked for adverse effects at 2000mg/kg and found none. That indicates a very large therapeutic margin. Of course it's in mice, not people....

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Re:Chemical clears Alzheimer's protein and restores memory i... by termain on Thursday December 17, 2015 @10:00AM (#10751797)

Edit: Ok, ok, I totally screwed that up. Damnit. Sorry, everyone. Grams aren't kilograms. The freaking base unit shouldn't have a prefix.

2000mg/kg = 2, right?

Like 2kg of medicine for every one kg of body mass? That seems impossible to consume. Even 0.1 kg/kg seems really, really high.

Or is mg here used for micrograms rather than milligrams? So it's actually 2000 μg/kg.

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Re:Chemical clears Alzheimer's protein and restores memory i... by zeristor on Thursday December 17, 2015 @10:03AM (#10751816)

2000 mg is 2g (a kg is 1000g, or 1 x 10^6mg)

Have you worked on software for NASA Mars probes in the past?

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Re:Chemical clears Alzheimer's protein and restores memory i... by termain on Thursday December 17, 2015 @11:02AM (#10752213)

Err.... NASA software, yes. No Mars probes yet.

Yeah, I know, I know.

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Re:Chemical clears Alzheimer's protein and restores memory i... by zeristor on Thursday December 17, 2015 @12:44PM (#10752951)

I really need to be less sarcastic.

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Re:Chemical clears Alzheimer's protein and restores memory i... by termain on Thursday December 17, 2015 @03:45PM (#10754407)

It was the perfect comment.

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Re:Chemical clears Alzheimer's protein and restores memory i... by sneak on Thursday December 17, 2015 @01:50PM (#10753498)

I concur entirely. You had ought to be ashamed of yourself.

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Re:Chemical clears Alzheimer's protein and restores memory i... by dsr_ on Thursday December 17, 2015 @10:03AM (#10751815)

2g of drug per kilogram of body mass. That's not the therapeutic dose, that's the safety limit.

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Re:Chemical clears Alzheimer's protein and restores memory i... by gboss on Thursday December 17, 2015 @10:05AM (#10751824)

2000mg = 2 grams not 2 kilograms. So it would be 2 grams per kilogram.

2kg = 20000000mg.

Hope that clears that up.

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Re:Chemical clears Alzheimer's protein and restores memory i... by kilburn on Thursday December 17, 2015 @10:12AM (#10751876)

Wrong. 2000mg/Kg = 2g/Kg, two grams of the chemical per kilogram (1000g) of the subject. To give you an idea, that's 160g of chemical for an 80Kg human. Quite a lot, but nowhere near impossible to consume...

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Re:Chemical clears Alzheimer's protein and restores memory i... by 4ad on Thursday December 17, 2015 @10:14AM (#10751891)

Actually it's just something between 0.8g and 8g, 160g is a safe limit, not the therapeutic dose.

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Re:Chemical clears Alzheimer's protein and restores memory i... by 4ad on Thursday December 17, 2015 @10:03AM (#10751811)

> 2000mg/kg = 2, right?

No, 2000mg/kg = 0.002

> Like 2kg of medicine for every one kg of body mass?

No, 2g for every kg of body. And that's some safe limit, not therapeutic dose.

> Or is mg here used for micrograms rather than milligrams?

No, it's milligrams.

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